Table 1.

Genome-wide heritability of the 38 cancers in the UK BioBank.

ICD10MalignancyCasesPrevalenceEmbedded ImageEmbedded ImageEmbedded ImageHL
C44Other malignant neoplasms of skin9,0860.02521.14080.03410.2422422
C50Malignant neoplasm of breast8,3040.02301.08690.01700.1285267
C61Malignant neoplasm of prostate4,3420.01201.07650.01910.2320271
C18Malignant neoplasm of colon2,2260.00621.03990.00700.141633
C43Malignant melanoma of skin1,6720.00461.02880.00510.129352
C15Malignant neoplasm of esophagus5190.00141.02360.00350.229624
C67Malignant neoplasm of bladder1,5540.00431.02220.00470.125439
C34Malignant neoplasm of bronchus and lung1,4270.00401.02080.00350.101017
C20Malignant neoplasm of rectum1,1180.00311.01300.00310.109115
C62Malignant neoplasm of testis2210.00061.01200.00240.315829
C71Malignant neoplasm of brain3680.00101.01160.00300.257819
C45Mesothelioma1500.00041.01100.00120.22135
C91Lymphoid leukemia3490.00101.01090.00180.164611
C02Malignant neoplasm of other and unspecified parts of tongue1520.00041.01060.00130.247523
C16Malignant neoplasm of stomach3880.00111.01060.00100.086812
C83Diffuse non-Hodgkin lymphoma5870.00161.01040.00140.082414
C82Follicular (nodular) non-Hodgkin lymphoma3200.00091.01010.00310.305921
C90Multiple myeloma and malignant plasma cell neoplasms4010.00111.00920.00130.102015
C56Malignant neoplasm of ovary6930.00191.00630.00120.061613
C54Malignant neoplasm of corpus uteri9880.00271.00630.00080.029514
C48Malignant neoplasm of retroperitoneum and peritoneum1220.00031.00530.00090.20645
C64Malignant neoplasm of kidney except renal pelvis7010.00191.00430.00090.045510
C01Malignant neoplasm of base of tongue1020.00031.00430.00140.359610
C73Malignant neoplasm of thyroid gland2780.00081.00420.00110.125413
C49Malignant neoplasm of other connective and soft tissue2220.00061.00400.00170.222928
C80Malignant neoplasm without specification of site3980.00111.00400.00160.130014
C53Malignant neoplasm of cervix uteri1920.00051.00390.00050.070914
C22Malignant neoplasm of liver and intrahepatic bile ducts1890.00051.00310.00090.13537
C21Malignant neoplasm of anus and anal canal1390.00041.00270.00070.143623
C85Other and unspecified types of non-Hodgkin lymphoma7620.00211.00230.00130.06009
C09Malignant neoplasm of tonsil1620.00041.00220.00060.10095
C92Myeloid leukemia3280.00091.00110.00080.07649
C17Malignant neoplasm of small intestine1140.00031.00070.00150.359612
C19Malignant neoplasm of rectosigmoid junction4980.00140.99920.00060.039010
C25Malignant neoplasm of pancreas4030.00110.99910.00050.040212
C81Hodgkin's disease1500.00040.99890.00030.05975
C69Malignant neoplasm of eye and adnexa1370.00040.99700.00040.070514
C32Malignant neoplasm of larynx1590.00040.99140.00030.04507
  • Note: For each cancer, we report the number of cases, the prevalence in the cohort, the average Embedded Image of the SNPs considered in the GWAS analysis (Embedded Image), the genome-wide estimates of heritability, both on the observed (Embedded Image) and the liability (Embedded Image) scale, and the number of heritability loci (HL) reported by BAGHERA as significant for Embedded Image. In bold, we denote the 16 cancers that we used for the downstream analysis and functional characterization.